Journal of the Korean Academy of Pediatric Dentistry 2008;35(1):144-150.
Published online February 29, 2008.
DEVELOPMENTAL DISTURBANCE OF PERMANENT TEETH AFTER RADIOTHERAPY FOR TREATMENT OF MALIGNANT TUMOR : REPORT OF CASES
Su-Kyung Heo, Nam-Ki Choi, Seon-Mi Kim, Kyu-Ho Yang
Department of Pediatric Dentistry, School of Dentistry, Chonnam National University, Dental Research Institute and Second stage of BK21 
소아암 환자에서 방사선 치료 후 영구치 치근발육장애 : 증례보고
허수경, 최남기, 김선미, 양규호
전남대학교 치의학전문대학원 소아치과학교실, 치의학 연구소 및 2단계 BK21 사업단
Correspondence:  Nam-Ki Choi,  Tel: 062-220-5476, Email: hellopedo@hanmail.net
Abstract
Multimodal cancer therapy including surgery, chemotherapy, and radiotherapy could not only improve the prognosis of malignancy but also reduce the dosage and toxicity of cancer drug for treatment of malignant tumor. The effects of radiotherapy are generally localized, additive, and accumulative, and depend on dosage, site and cell sensitivity. However, in growing individuals, the dental and skeletal sequelae to radiotherapy result in dental or facial abnormalities that are irreversible : arrested root development, disturbances in enamel formation, microdontia, anodontia, altered tooth eruption and mandibular or maxillary hypoplasia. Especially, the teeth which are developing is affected according to the stage. We report three cases of developmental disturbance of permanent teeth after radiotherapy. These children had received radiotherapy for malignant tumor at the age of 3 to 4 years, in which root hypoplasia, short tapered root and early apex closure were observed. For the management of radiation caries and radiotherapy-related teeth, periodic recall check and oral hygiene instruction are required.
Key Words: Radiotherapy, Developmental disturbance of permanent teeth


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