Journal of the Korean Academy of Pediatric Dentistry 2009;36(4):531-538.
Published online November 30, 2009.
INHIBITION OF GLUCAN SYNTHESIS RELATED GENE EXPRESSION OF STREPTOCOCCUS MUTANS BY XYLITOL TREATMENT
1경북대학교 치의학전문대학원 예방치과학교실
2동국대학교 의과대학 치과학교실
3경북대학교 치의학전문대학원 소아치과학교실 
자일리톨 섭취에 따른 Streptococcus mutans의 글루칸 생성관련 유전자 발현 억제효과
김지혜1, 이영은1, 안상헌2, 최연희1, 남순현3, 송근배1
1경북대학교 치의학전문대학원 예방치과학교실
2동국대학교 의과대학 치과학교실
3경북대학교 치의학전문대학원 소아치과학교실
Correspondence:  , 
Received: 23 April 2009   • Accepted: 14 August 2009
Abstract
Xylitol has the ability to reduce the adherence of Streptococcus mutans(S. mutans), which can make it easier to remove plaque, decrease acid production and inhibit dental caries. There are few reports on the effects of xylitol on the expression of the virulence related genes in S. mutans. This study examined the inhibitory effect of chewing gum containing xylitol on glucan synthesis related gene expression of S. mutans. Participants were voluntarily recruited for a women's oral health prevention program, classified into two groups(a control and a xylitol group), and then followed for 2 years. Twenty salivary samples were randomly selected from each group. Colony count and real-time reverse transcription polymerase chain reaction were used to analyze the characteristics of S. mutans. The following results were obtained: The S. mutans counts decreased steadily in the xylitol group over the study period(p<0.05). The expression of the virulence related genes (gtfB, gtfC and gtfD) was significantly lower in the xylitol group than in the control groups (p<0.05). In conclusion, these results suggest that chewing xylitol gum for a long period of time may reduce the expression of the genes associated with S. mutans virulence, which can result in a decrease growth of S. mutans colonies as a result.
Key Words: Glucan synthesis related gene, Streptococcus mutans, Xylitol


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