THE EFFECT OF PHOTODYNAMIC THERAPY ON THE VIABILITY OF STREPTOCOCCUS MUTANS ISOLATED FROM ORAL CAVITY
Ji-Sook Jung1, Ho-Won Park1, Ju-Hyun Lee1, Hyun-Woo Seo1, Si-Young Lee2
1Department of Pediatric Dentistry,College of Dentistry, Gangneung-Wonju National University
2Department of Microbiology and Immunology, Oral Science Research Center, College of Dentistry, Gangneung-Wonju National University
Corresponding Author: Ju-Hyun Lee ,Tel: 033-640-2452, Email: ljh55@gwnu.ac.kr
Received: February 7, 2012;  Accepted: July 31, 2012.
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ABSTRACT
Photodynamic therapy (PDT) is a technique that involves the activation of photosensitizer by light in the presence of tissue oxygen, resulting in the production of reactive radicals capable of inducing cell death. The aim of this study was to evaluate the effect of PDT on Streptococcus mutans in planktonic conditions, previously treated with different photosensitive concentrations of erythrosine, using halogen and LED curing unit as a light source. And we compared the effects of PDT on six strains of S. mutans isolated from oral cavity and reference strain. As a result, S. mutans was susceptible to the combination of hand held photopolymerizer (HHP) and erythrosine. The higher concentration of erythrosine in the presence of light irradiation induced greater effects in reduction of viability of S. mutans. Isolated S. mutans showed a significant reduction in bacterial counts of the groups submitted to PDT compared to the control groups. And they appeared to be similar or slightly lower antimicrobial effect compared with reference strain. However, the difference was not significant (p < 0.05). In conclusion, PDT using erythrosine as a photosensitizing agent and HHP as a light source could be an efficient option for diseases caused by S. mutans.
Keywords: Photodynamic therapy | Erythrosine | Halogen | LED | Streptococcus mutans
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