| A STUDY ON THE FRACTIONAL INHIBITORY CONCENTRATION(FIC) INDEX OF COMBINATIONS OF ANTICARIOGENIC AGENTS |
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| 항우식작용을 갖는 여러 항균물질의 조합에 따른 분할 저해 농도(FIC ; Fractional inhibitory concentration) 지수에 대한 연구 |
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김영재1, 김종철1, 김각균2 |
1서울대학교 치과대학 소아치과학교실, 서울대학교 치과대학 치학연구소
2서울대학교 치과대학 구강미생물학교실, 서울대학교 치과대학 치학연구소 |
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| Abstract |
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The effect of combinations of 8 antimicrobial agents on the growth of Streptococcus mutans and Streptococcus sobrinus was investigated with the minimum inhibitory concentration and fractional inhibitory concentration(FIC) and ∑FIC index. According to the ∑FIC values by. The American Society for Microbiology and Berenbaum, Approximately 34% and 82% of the combinations were synergistic respectively. Partial synergy described by Isenberg was also observed in the half of the combinations. There was a tendency for additive antimicrobial effect against cariogenic bacteria though the test results showed difference according to the applied values. It may be beneficial to use combined antimicrobial agents that have various activities against an ecosystem and metabolism of bacteria than using individual agents. |
| Key Words:
Fractional inhibitory concentration index, Anticariogenic, Cariogenic bacteria, Synergistic |
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