COMPARISON OF SEDATIVE EFFECTS BETWEEN THREE ROUTES OF ADMINISTRATION WITH MIDAZOLAM

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Journal of the Korean Academy of Pediatric Dentistry 2000;27(2):283-291.
Published online May 31, 2000.

COMPARISON OF SEDATIVE EFFECTS BETWEEN THREE ROUTES OF ADMINISTRATION WITH MIDAZOLAM

Midazolam의 투여방법에 따른 진정효과의 비교연구

김령, 이긍호

경희대학교 치과대학 소아치과학교실

Abstract

The purpose of this study was to compare the sedative effect of three routes of administration - intramuscular, intranasal drop-in, intranasal spray - with midazolam. The twenty two uncooperative children from 23 months to 76 months who required at least three dental appointment. Each patient was assigned randomly to receive intramuscular(Group I, 0.15mg/kg), intranasal drop-in(Group II, 0.20mg/kg), intranasal spray(Group III, 0.20mg/kg) administration at each visit. Sleep, crying, movement, and overall behavior response were evaluated, and the sedative effects were evaluated by Houpt's rating scale In order to monitor the sedated patients, pulse rate and peripheral oxygen saturation were measured by pulse oximeter during treatment procedures. The results were as follows 1. Pulse rate and peripheral oxygen saturation were stable through all the treatment procedures, and there were no statistically significant differences among three routes of administration(P>0.05). 2. The effect on sleep was, III, II, I, in order, III group was the most effective through all the treatment procedures, except rubber-dam placement and filling phase (P<0.0001). 3. The effects on crying, movement, overall behavior were II, III, I, in order, II group was the most effective through all treatment procedures(P<0.0001).

Key Words: Midazolam, Intramuscular, Intranasal drop-in, Intranasal spray