Journal of the Korean Academy of Pediatric Dentistry 1996;23(4):775-787.
Published online November 30, 1996.
IMMUNOHISTOCHEMICAL STUDY ON THE POSTNATAL DEVELOPMENT OF DENTAL PULP INNERVATION IN RAT POSTERIOR TEETH
1
2 
출생후 흰쥐 구치의 발육에 따른 치수의 신경지배 발달에 관한 면역조직화학적 연구
김동길1, 김현정1, 남순현1, 배용철2, 김영진1
1경북대학교 치과대학 소아치과학교실
2경북대학교 치과대학 구강해부학교실
Abstract
The purpose of this study was to investigate the postnatal development of pulpal innervation with the tooth development and eruption process in developing rat mandibular molars (postnatal 1, 5, 10, 15, 20, 25, 35day-old and adult rats). Immunohistochemical method was carried out for the detection of nerve fibers, using the antibody against calcitonin gene-related peptide(CGRP). The results were as follows: The feature of CGRP-IR nerve fibers were shown in a bead-like appearance. The time of nerve entering into the dental papilla of tooth follicle began at the occured advanced dentinogenesis. The development of Raschkow plexus began at the formative stage of the roots and was accelerated at the stage of the crown emerged into the oral cavity. The number of nerve fibers entering the odontoblastic layer increased with the tooth eruption and mastication. The development of innervation was shown to be related with the stage of the development of individual teeth rather than the chronological age of the rat.


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