Journal of the Korean Academy of Pediatric Dentistry 2009;36(4):505-513.
Published online November 30, 2009.
ANTIMICROBIAL ACTIVITY OF ARTEMISIA SPECIES AGAINST CLINICALLY ISOLATED STREPTOCOCCUS MUTANS
Jung-Ah Seo, Jae-Gon Kim, Mi-Ah Kim, Byeong-Ju Baik, Yeon-Mi Yang, Jin-Woo Jeong
전북대학교 치의학전문대학원 및 구강생체과학연구소 
Correspondence:  Jae-Gon Kim, 
Received: 6 April 2009   • Accepted: 15 September 2009
Abstract
Streptococcus mutans plays a major role in the formation of dental plaque and it is considered one of the important pathogens in the development of dental caries. Established dental plaque can be more resistant to antimicrobial agents and offers nutrient rich and relatively stable cariogenic conditions for bacteria. Thus bacteria growing in dental plaque have strong resistance to antimicrobial agents and they are not removed easily by the flow of saliva. Many researchers have been performed using natural materials, especially herbal extracts to prevent dental plaque. However, the strains of mutans streptococci used in the researches were not from Koreans. Therefore, it would be necessary to evaluate the antimicrobial activity of herbal extracts against clinical isolates of Streptococcus mutans isolated from saliva of Koreans living in Jeollabuk-do. For this study four clinical isolates were isolated from saliva samples of seventeen Korean people to investigate whether essential oils of Artemisia spp. have antimicrobial activity against them including four reference strains of Streptococcus mutans. Minimum inhibitory concentrations, Minimum bactericidal concentrations and time kill studies were performed and the results showed that Artemisia lavandulaefolia DC, Artemisia scoparia, and Artemisia capillaries have antimicrobial activity against the Streptococcus mutans clinical isolates and reference strains.
Key Words: Artemisia, Antimicrobial agent, Streptococcus mutans


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