| THE MANDIBULAR GROWTH EFFECT OF THE BOTULINUM TOXIN TYPE A INJECTION INTO UNILATERAL MASSSTER MUSCLE OF GROWING RAT |
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So-Youn Kwak, Ki-Tae Park, Ji-Yeon Kim |
| Department of Pediatric Dentistry, Samsung Medical Center, Sungkyunkwan University School of Medicine |
| 성장기 쥐의 편측 교근에 주사한 보툴리눔 A형 독소가 하악골 성장에 미치는 영향 |
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곽소연, 박기태, 김지연 |
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성균관대학교 의과대학 삼성서울병원 치과진료부 소아치과 |
Correspondence:
Ji-Yeon Kim, Tel: 02-3410-2409, Email: jychaee@skku.edu
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Received: 5 December 2008 • Accepted: 8 June 2009 |
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| Abstract |
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The purpose of this study was to assess the effect on mandibular growth of botulinum toxin type A (BTXA) injection into the unilateral massester muscle of growing rats at three different growing stages. Thirty six male Sprague-Dawley rats were divided into three groups according to the age (group 1: 4 week-old, group 2: 5week-old, group 3: 6week-old). Then each group was randomly divided into 3 subgroups (control group, unilateral injection group, bilateral injection group). Experimental animals were sacrificed after 4 weeks. Then the jaw measurements were evaluated. The results were as follows: 1. In the group 1, mandibular body length, condylar height and coronoid process height of the unilateral group(BTXA side) and the bilateral group were shorter than those of the control group (p<0.05). 2. In the group 2, anterior region height, condylar height, coronoid process height of the unilateral group(BTXA side) and the bilateral group were shorter than those of the control group (p<0.05). 3. In the group 3, mandibular body length, condylar height, coronoid process height of the unilateral group(BTXA side) and the bilateral group were shorter than those of the control group (p<0.05). 4. There was no significant difference in mandibular measurements between the control side and the injection side in the unilateral group in all age groups (p>0.05). |
| Key Words:
Botulinum type A toxin, Mandibular growth, Functional matrix |
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