| EFFECT OF ADMINSTRATION METHOD OF FLUMAZENIL ON THE PLASMA CONCENTRATION AND THE REVERSAL OF SEDATION INDUCED BY MIDAZOLAM |
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Seong-Kyu Park, Sang-Ho Lee, Chang-Seop Lee, Nan-Young Lee, You-Hyang Oh |
| Department of Dentistry, College of Dentistry, Chosun University |
| Flumazenil의 투여 방법에 따른 혈장내 농도와 midazolam에 의해 유도된 진정 상태의 환원 효과 |
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박성규, 이상호, 이창섭, 이난영, 오유향 |
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조선대학교 치과대학 소아치과학교실 |
Correspondence:
Sang-Ho Lee, Tel: 062-220-3860, Fax: 062-225-8240, Email: shclee@chosun.ac.kr
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| Abstract |
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The purpose of this study were to evaluate the effect on the reversion of sedation induced by midazolam with flumazenil and to determine the plasma concentration of flumazenil according to the method of administration. Intranasal and intravenous flumazenil were administered to sedated health volunteers aged from 23 to 25 years, in doses typical of those used clinically to induce sedation with midazolam and for reversal with flumazenil. Objective assessment for degree of sedation and vital signs, plasma concentration were made for 2 hours period. 1. Systolic and diastolic blood pressure, SpO2 were not changed by adminstration of flumazenil in sedated subject with midazolam, but pulse rate was increased temporarily. 2. Flumazenil showed the reversal of the sedative effect induced by midazolam regardless of administration methods. But intravenous administration showed more effect on the degree and the duration of reversion than intranasal administration with the exception of on set time. 3. Peak plasma concentration of flumazenil administered by intranasal route reached after 2 min and that of flumazenil administered by intravenous route was 4 min. Thus uptake of flumazenil did not showed any difference in accordance with the adminstration route. 4. Administration of flumazenil resulted in the temporary increase of midazolam plasma concentration. |
| Key Words:
Flumazenil, Midazolam, Sedation, Antagonic effect, Vital sign |
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