COMPARATIVE EVALUATION OF INTRANASAL AND ORAL MIDAZOLAM

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Journal of the Korean Academy of Pediatric Dentistry 2004;31(3):431-438.
Published online August 31, 2004.

COMPARATIVE EVALUATION OF INTRANASAL AND ORAL MIDAZOLAM

Midazolam의 경비투여와 경구투여 시 진정효과에 대한 비교연구

박헌동, 이창섭, 이상호, 이난영

조선대학교 치과대학 소아치과학교실

Correspondence: ,

Abstract

The purpose of present study was to compare the sedative effect of intranasal and oral midazolam treatment. The study was conducted on twenty eight child patients who required at least two visits. All the patients showed a good physical status (ASA-I). The patient was randomly assigned to receive midazolam either intranasal (Group I, 0.25 mg/kg) or oral (Group II, 0.5mg/kg) route at each visit. Treatment procedure was divided into six stages. In each stage, sleep score, crying score, movement score and overall behavior score were evaluated. The overall results can be summarized as follows: 1. Through all treatment procedures, no significant difference was observed between Group I and Group II in terms of sleep, crying, movement and overall behavior index. 2. In a questionnaire to the parents, 67.8% of parents answered that the child suffered at intranasal administration, while only 17.7% of parents responded the same way at oral administration. 3. In a questionnaire regarding patients' behavior at home after midazolam treatment, 'Similar to normal behavior' was 78.6% in Group I and 57.1% in Group II, indicating that intranasal treatment of midazolam may be more effective for the recovery.

Key Words: Sedation, Midazolam, Intranasal administration, Oral administration