Journal of the Korean Academy of Pediatric Dentistry 2003;30(1):61-68.
Published online February 28, 2003.
ANTIBODY PRODUCTION BY PARENTERAL ADMINISTRATION OF STREPTOCOCCUS MUTANS AND GLUCOSYLTRANSFERASE IN MICE
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비경구 투여한 Streptococcus mutans 균체 및 Glucosyltransferase에 대한 마우스의 면역항체반응
양규호1, 정미1, 정진4, 장미영2, 오종석2, 나희삼2, 강인철3, 이현철2
1전남대학교 치과대학 소아치과학교실, 치의학연구소
2전남대학교 의과대학 미생물학교실
3전남대학교 치과대학 구강미생물학교실
4부산대학교 치과대학 구강미생물학교실
Abstract
Streptococcus mutans is known to be a major causative organism of human dental caries. The development of a vaccine against dental caries involves identification of appropriate antigens of mutans streptococci against which protective immune responses can be mounted, and the selection of a method of immunization that will generate sustained levels of protective antibodies. Antigens receiving most attention include streptococcal surface proteins that are involved in attachment to tooth surfaces and glucosyltransferases (GTF) that synthesize adhesive glucans from sucrose. The induction of antibody responses to orally administered antigens is often difficult due to digestive destruction of antigens and immune tolerance. Here we report the induction of antibody responses to an anti-caries vaccine containing retinoic acid (RA). Subcutaneous immunization with formalin-fixed bacteria or GTF supplemented with RA induced higher serum IgM and IgA responses to GTF compaired to oral adminstration. Antisera induced by Ingbritt strain showed partial cross-reaction with LM-7 strain, but not with OMZ175. These results suggest that subcutaneous immunization with GTF combined with an immunomodulator, RA, may be applied to anti-caries vaccine.
Key Words: Streptococcus mutans, Glucosyltransferase (GTF), Retinoic acid, IgA


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