Journal of the Korean Academy of Pediatric Dentistry 2009;36(2):217-226.
Published online May 31, 2009.
STUDY ON COMPARISON OF ANTIMICROBIAL ACTIVITY BETWEEN HORSERADISH(ARMORACIA RUSTICANA) ROOT EXTRACTS AND SYNTHETIC ALLYL ISOTHIOCYANATE AGAINST ORAL PATHOGENIC MICROORGANISMS
1강릉대학교 치과대학 소아청소년치과학교실 및 구강과학연구소
2강릉대학교 해양생명공학부 식품미생물학교실 
구강 내 미생물에 대한 서양산 고추냉이 (Horseradish, Armoracia rusticana) 뿌리 천연추출물과 합성 Allyl isothiocyanate의 항균활성 비교
박광선1, 박호원1, 신일식2, 이주현1, 서현우1
1강릉대학교 치과대학 소아청소년치과학교실 및 구강과학연구소
2강릉대학교 해양생명공학부 식품미생물학교실
Correspondence:  , 
Received: 10 November 2008   • Accepted: 16 February 2009
Abstract
Allyl isothiocyanate (AIT), the principle ingredient of antimicrobial ingredients from horseradish root, can be prepared from extracts of horseradish root or synthetic method. It is reported that the horseradish root extract has the antimicrobial effect against various oral microorganisms, while there is no further study about the antimicrobial effect against the oral microorganisms of synthetic AIT derived from synthetic method. The aim of the study is to compare the difference of the antimicrobial effect between horseradish root extracts and synthetic AIT. To evaluate the antimicrobial effect, we measured the minimum inhibitory concentration(MIC) and minimum bactericidal concentration (MBC), and the results are like following. 1. The MIC of horseradish root extract against 7 kinds of oral pathogenic microorganisms is about 117~1,750 ppm(0.0117~0.175%), and the MIC of the synthetic AIT is about 344 ~3,000 ppm(0.0344~0.3%), which have the antimicrobial effects against all kinds of microorganisms. 2. The MBC of the horseradish root extracts against the 7 kinds of oral microorganisms is about 625.2~지6,000 ppm(0.06252~0.6%), and the MBC of the synthetic AIT is about 1,750~7,000 ppm(0.175~0.7%), which have the antimicrobial effects against all kinds of microorganisms.
Key Words: Horseradish(Armoracia rusticana), Natural extract, Allyl isothiocyanate(AIT), Wasabi, Antimicrobial activity


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