Journal of the Korean Academy of Pediatric Dentistry 2005;32(3):517-524.
Published online August 31, 2005.
A COMPARISON OF THE SEDATIVE EFFECT ON CHLORAL HYDRATE DOSAGE IN THE SEDATION OF THE PEDIATRIC DENTAL PATIENTS
Seung-Chul Rho, Young-Jae Kim, Ki-Taeg Jang, Se-Hyun Hahn
Department of Pediatric Dentistry and Dental Research Institute, College of Dentistry, Seoul National University 
소아환자 진정요법에서 chloral hydrate의 용량에 따른 진정효과에 관한 연구
노승철, 김영재, 장기택, 한세현
서울대학교 치과대학 소아치과학교실
Correspondence:  Se-Hyun Hahn,  Tel: 02-2072-2607, Email: shhan@snu.ac.kr
Abstract
Despite the widespread use of chloral hydrate with hydroxyzine in the sedation of children, there is little agreement among pediatric dentists regarding its therapeutic dosage for the management of very uncooperative young children. Also, increasing concern has been raised with respect to its frequent failure to provide adequate levels of sedation when used according to the manufacturer's recommended dosage. Therefore, there has been many suggestions with respect to sedative effectiveness and safety of varying drug dosage, and some pediatric dental articles have advocated dosages exceeding manufacturer's recommendations. This study was performed to compare the effectiveness and safety in behavior management of the manufacturer's recommended dose of chloral hydrate(50mg/kg) with those of a higher dose(70mg/kg) used together with hydroxyzine(2mg/kg) and nitrous oxide(50%) when young children were sedated for dental treatment. The following results were obtained; 1. II group(70mg/kg) displayed higher mean score compared to I group(50mg/kg) with regard to the degree of sleep, crying, movement and overall behavior. The difference was statistically significant(p<0.05). 2. In comparison of success rates for sedation between the two groups, I group and II group showed 38.7% and 71.0% success rates respectively. An analysis of variance was statistically significant(p<0.05). 3. Comparing the occurrence rate hypoxia between the two groups, there were 22.6% and 19.4% occurrence of hypoxia in I group and II group. An analysis of variance was not statistically significant(p>0.05).
Key Words: Chloral hydrate, Sedation, Drug dosage, Overall behavior, Hypoxia


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