| DISPLACEMENT OF MAXILLARY LATERAL INCISOR CAUSED BY IDIOPATHIC GINGIVAL FIBROMATOSIS |
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Ji-Sook Jung1, Ho-Won Park1, Ju-Hyun Lee1, Hyun-Woo Seo1, Suk-Keun Lee2 |
1Department of Pediatric Dentistry, College of Dentistry, Gangneung-Wonju National University
2Department of Oral Pathology, Oral Science Research Center, College of Dentistry, Gangneung-Wonju National University |
| 특발성 치은 섬유종증에 의한 상악 측절치의 변위 |
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정지숙1, 박호원1, 이주현1, 서현우1, 이석근2 |
1강릉원주대학교 치과대학 소아치과학교실
2강릉원주대학교 치과대학 구강병리학교실 및 구강과학연구소 |
Correspondence:
Ho-Won Park, Tel: 033-640-2464, Email: pedo@gwnu.ac.kr
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Received: 18 July 2011 • Accepted: 17 August 2011 |
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| Abstract |
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Idiopathic gingival fibromatosisrarely occurs, but frequently recurred after surgical removal. It usually occurs in generalized symmetrical pattern but sometimes in localized unilateral pattern. The localized pattern usually affects the maxillary molar and tuberosity area. This disease usually causes tooth migration, malocclusion, and problems in eating, speech, and esthetics. A boy showed dense gingival fibromatosis localized at primary maxillary right lateral incisor area at the age of 5 years, and his maxillary right lateral incisor become severely displaced at the age of 9 years. He had no medical and hereditary factors relevant to the gingival fibromatosis. However, the dense fibrous tissue was dominant in his labial gingiva of maxillary right incisors. In order to realign the displaced incisors by orthodontic treatment, the dense fibrous tissue covered the defect space between the central incisor and the displaced lateral incisor was surgically removed. The removed specimen was examined by simple immunohistochemical(IHC) array method. IHC array showed increased expression of CTGF, HSP-70, MMP-1, PCNA, CMG2, and TNF-αin keratinocytes, fibroblasts, endothelial cells, and macrophages of gingival fibromatosis tissue. Therefore, it was suggested that the gingival fibromatosis be caused by the concomitant overexpression of CTGF, HSP-70, MMP-1, PCNA, CMG2, and TNF-α,and resulted in the fibroepithelial proliferation and the inflammatory reaction of gingival tissue. |
| Key Words:
Gingival overgrowth, Idiopathic gingival fibromatosis, Tooth displacement, Immunohistochemical
array method |
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