A COMPARATIVE EVALUATION OF ORAL CHLORAL HYDRATE VS. ORAL MIDAZOLAM IN SEDATIVE EFFECT

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Journal of the Korean Academy of Pediatric Dentistry 2005;32(1):40-48.
Published online February 28, 2005.

A COMPARATIVE EVALUATION OF ORAL CHLORAL HYDRATE VS. ORAL MIDAZOLAM IN SEDATIVE EFFECT

조선대학교 치과대학 소아치과학교실

Chloral hydrate와 Midazolam의 경구투여시 진정효과에 대한 비교

오명신, 이창섭, 이상호, 이난영

조선대학교 치과대학 소아치과학교실

Correspondence: ,

Abstract

The purpose of present study was to compare the sedative effect of chloral hydrate and oral midazolam treatment. The study was conducted on twenty two child patients who required at least two visits. All the patients showed a good physical status (ASA-I). The patient was randomly assigned to receive drug either chloral hydrate 60mg/kg and hydroxyzine 25mg(Group I) or midazolam 0.5mg/kg and hydroxyzine 25mg(Group II) at each visit. Treatment procedures were divided into six stages. In each stage, sleep, crying, movement and overall behavior score were evaluated. The overall results can be summarized as follows: 1. Success rate was 59.9% in group I and was 77.8% in Group II. 2. Mean sleep score was 1.81±0.93 in group I and was 1.44±0.69 in group II (P<0.05). 3. Through all treatment procedures, no significant difference was observed between group I and group II in terms of crying, movement and overall behavior score(P>0.05). 4. There was no significant difference between the sex and the age(P>0.05). In regard to above results, oral midazolam considered to be a valuable drug as sedative agent in pediatric dentistry.

Key Words: Sedation, Chloral hydrate, Midazolam, Oral administration