| Comparison of Behavioral Response between Intranasal and Submucosal Midazolam Adminstration |
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Yun-Hee Kim1, Sang-Hyuk Jung2, Kwang-Woo Baek1 |
1Department of Pediatric Dentistry, Ewha Womans University Graduate School of Clinical Dentistry,
2Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Korea |
| 소아 진정 치료 시 구강 점막 하와 비점막 Midazolam 투여의 행동 반응 비교 |
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김윤희1, 정상혁2, 백광우1 |
1이화여자대학교 목동병원 소아치과학교실
2이화여자대학교 목동병원 의과대학 예방의학교실 |
Correspondence:
Kwang-Woo Baek, Tel: 02-2650-2660, Email: pedobaek@ewha.ac.kr
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Received: 22 May 2008 • Accepted: 4 June 2008 |
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| Abstract |
Purpose
. The objective of this study was to evaluate the behavioral response and assess the effectiveness of additional intranasal (IN) and submucosal (SM) administration of midazolam during pediatric sedation for dental procedure. Material and methods. Thirty-three cases of healthy (ASAⅠ), uncooperative children aged from 24 to 72 month old at pediatric dental clinic of Ewha Womans University Hospital were selected for this study. Children received oral chloral hydrate 50 mg/kg with hydroxyzine 1.0 mg/kg. After waiting for 45 minutes, midazolam 0.2 mg/kg was administrated via IN route and via SM route randomly maintaining 50% of N2O. A pulse oximeter and a capnograph were used for measuring vital signs (SpO2, PR, RR, EtCO2) throughout the sedation. Behavioral response was evaluated as Quiet (Q), Crying (C), Movement (M) or Struggling (S) in every 2 minutes for 40 minutes. Results. There were also no statistically significant differences in vital signs of the two groups. The behavioral response for the first ten minutes during sedation was a statistically significant difference (P < 0.05) between the two groups. After the first ten minutes, it was revealed that there was no significant difference. Conclusion. This study demonstrated that the addition of IN midazolam to the combination of oral chloral hydrate with hydroxyzine and nitrous oxide/oxygen inhalation is as safe and effective as that of SM midazolam in pediatric sedation for dental procedure. |
| Key Words:
Sedation, Submucosal midazolam, Intranasal midazolam, Chloral hydrate |
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