Journal of the Korean Academy of Pediatric Dentistry 2008;35(4):671-676.
Published online November 30, 2008.
The Relationship between the Salivary IgA against AgI/II of S. mutans and Dental Caries Experience among Children and Adults
Su-Min Lim, Jae-Gon Kim, Byeong-Ju Baik, Yeon-Mi Yang, Su-Kyung Kim, Kyung-Yol Lee
Department of Pediatric Dentistry and Institute of Oral Bioscience, School of Dentistry, Chonbuk National University 
Correspondence:  Jae-Gon Kim,  Tel: 063-250-2121, Email: pedokjg@moak.chonbuk.ac.kr
Received: 21 June 2008   • Accepted: 17 September 2008
Abstract
AgI/II of Streptococcus mutans(S. mutans) is an important virulence factor that contributes to the pathogenesis of S. mutans-induced dental caries. In oral cavity, salivary IgA antibodies act as safeguards against enormous challenges from oral bacteria. IgA antibodies inhibit adherence of cariogenic microorganisms to hard surfaces. Analysis of salivary IgA against AgI/II can be very useful diagnostic and powerful communication tools to the dental caries The purpose of this study was to investigate correlation between salivary AgI/II specific IgA and incidence of dental caries among children and young adults. Subjects consisted of 28 children and 18 adults. They were assigned to four groups : Group Ⅰ(deft index ≤ 3), Group Ⅱ(deft index ≥ 4), Group Ⅲ(DMFT index ≤ 3), Group Ⅳ(DMFT index ≥ 4) and they was divided two groups into caries resistant group and caries susceptible group. The study group were examined caries activity and their salivary IgA was evaluated by enzyme-linked immunosorbent assay. The results are as follows : 1. There was a positive correlation between the number of S. mutans and caries activity. 2. The titer of salivary IgA against the AgI/II was significantly higher in caries resistant group than caries susceptible group(p<0.01). 3. The titer of salivary IgA against the AgI/II in Group Ⅲ was significantly higher than GroupⅡ(p<0.05).
Key Words: Dental Caries, AgI/II, Salivary IgA, ELISA


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