IN VITRO STUDY ON CARIOGENIC POTENTIAL OF SYRUP-FORM MEDICINES FOR CHILDREN

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Journal of the Korean Academy of Pediatric Dentistry 2011;38(2):146-154.
Published online May 31, 2011.

IN VITRO STUDY ON CARIOGENIC POTENTIAL OF SYRUP-FORM MEDICINES FOR CHILDREN

원광대학교 치과대학 소아치과학교실

어린이용 시럽제의 우식유발능에 대한 생체 외 연구

임화신, 이광희, 라지영, 안소연, 김윤희

원광대학교 치과대학 소아치과학교실

Correspondence: ,

Received: 9 February 2011 • Accepted: 22 March 2011

Abstract

An in vitro study on cariogenic potential of 8 over-the-counter syrups for children was performed. The experimental groups were 8 over-the-counter syrups. The positive control group was 10% sucrose solution, and the negative control group was artificial saliva. The pH of each group was determined. The buffering capacity was measured by the volume of 2 N NaOH adding to equalize the pH of 20 ml of experimental solution to pH 7. The consistency was measured by the time to pass Ostwald pipette for 2 ml of the experimental solution. The experimental solutions were inoculated with S. mutans and cultured in 37℃ anaerobic condition for 48 hours. To estimate acid production, pH of the experimental solutions were measured before and after the culture. The primary teeth specimens were soaked in the experimental solutions for 20 minutes three times a day. Except on those hours the specimens were stored in artificial saliva. After 5 days, the microhardness changes of the specimens were measured. These results show that most of syrup-form medicines for children tend to have cariogenic potential partially in endogenous pH, buffering capacity, consistency, acid production and erosive ability of enamel. For the oral health of children, the alternative sweeteners (ex. xylitol) may be substituted for the cariogenic sweeteners of syrups. Additionally, It may be helpful that the chewable tablet replace liquid or syrup in term of dose form.

Key Words: Syrup form medicines, Cariogenic potential, Erosion of primary tooth, pH cycling model