| INHIBITORY EFFECT OF CRUDE IgY ON ACID PRODUCTION AND ENAMEL DEMINERALIZATION BY STREPTOCOCCUS MUTANS |
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| Streptococcus mutans의 산 생성과 법랑질 탈회에 대한 조난황항체(IgY)의 억제 효과 |
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오세영, 이광희, 김대업 |
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원광대학교 치과대학 소아치과학교실, 원광치의학연구소 |
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| Abstract |
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The purpose of study was to determine the effectiveness of crude IgY to S. mutans in preventing the acid production and the demineralization of primary tooth enamel in vitro. The acid production by S. mutans in Todd Hewitt broth with and without 5% sucrose was inhibited by 2.5% crude IgY, and as the concentration of crude IgY increased from 2.5% to 17.5%, the pH drop of the media after incubation continued to decrease. There were high positive correlations between the concentration of crude IgY and the pH of media in the late incubation period. The inhibition rate of demineralization of primary tooth enamel by S. mutans was determined by measuring the surface microhardness after incubation in 5% sucrose Todd Hewitt broth for 12 hours. The inhibition rate was 32.28% in 2.5% IgY, 42.28% in 7.5% IgY, 64.06% in 12.5% IgY, and 92.79% in 17.5% IgY. There was high positive correlation between the concentration of crude IgY and the surface microhardness of enamel after demineralization These results suggest that it would be possible to prevent dental caries through passive immunization using crude IgY. |
| Key Words:
IgY, Streptococcus mutans, Dental caries, Passive immunization |
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