THE EXPRESSION PATTERN OF BMPS AND THEIR RECEPTORS IN CALVARIAL SUTURE DEVELOPMENT

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Journal of the Korean Academy of Pediatric Dentistry 2002;29(3):345-353.
Published online August 31, 2002.

THE EXPRESSION PATTERN OF BMPS AND THEIR RECEPTORS IN CALVARIAL SUTURE DEVELOPMENT

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두개봉합부의 초기형태발생과정에서 BMP와 그 수용체의 발현 양상

윤양하¹, 이상원², 박미현², 류현모², 남순현¹, 김영진¹, 김현정¹

¹경북대학교 치과대학 소아치과학교실
²경북대학교 치과대학 구강생화학교실

Abstract

Bone morphogenetic proteins(BMPs) are secretory signal molecules which have a variety of regulatory functions during morphogenesis and cell differentiation. To evaluate roles of BMPs and their receptors on mouse sagittal suture development, we have examined their expression patterns in serial sections of sagittal sutures by in situ hybridization during embryonic stages(E15-E18). BMP-2 and BMP-3 were expressed in the osteogenic front and parietal bone on embryonic 15day, from E16 in hair follicle. BMP-4 was strongly expressed in the osteogenic front and weakly expressed in the mesenchyme and parietal bone. BMP-S was expressed in the hair follicles. BMP-6 was not expressed in this study. BMP-7 was expressed in parietal bone during embryonic stage. BMPR-IB was expressed in the osteogenic front, but BMPR-IA was not. From these datas, we suggest that the BMP-4 regulates the early commitment of mesenchymal cells to the osteogenic lineages, the BMP-2 and BMP-3 may be involved in regulating the differentiation of osteoblast precursor cells. BMP-7 was involved in maintenance of differentiated osteoblasts. BMPs were key signaling molecules that regulate early calvarial bone morphogenesis, mediated by BMPR-IB.

Key Words: BMP, BMP receptor, Sagittal suture, Osteogenic front, Osteoblast