THE COMPARATIVE STUDY ON THE EFFICACY OF CHLORAL HYDRATE AND HYDROXYZINE OF DIFFERENT DOSES IN SEDATING YOUNG PEDIATRIC DENTAL PATIENTS

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Journal of the Korean Academy of Pediatric Dentistry 2001;28(3):430-440.
Published online August 31, 2001.

THE COMPARATIVE STUDY ON THE EFFICACY OF CHLORAL HYDRATE AND HYDROXYZINE OF DIFFERENT DOSES IN SEDATING YOUNG PEDIATRIC DENTAL PATIENTS

Chloral hydrate와 병용투여 시 Hydroxyzine용량에 따른 진정효과의 비교연구

이인천, 김종수, 권순원

단국대학교 치과대학 소아치과학교실

Abstract

Orally administered chloral hydrate is often used, because of it's wide margin of safety and relatively few sideeffects. Hydroxyzine is an antihistamine with sedative and anti-emetic properties. It has been used in conjunction with chloral hydrate to reduce the incidence of nausea and vomiting. But, it's therapeutic drug concentration has not been established. The purpose of this study was to assess the sedative effect and physiologic parameter of hydroxyzine of different doses in sedating young pediatric dental patients. Fifty uncooperative children, mean age 33.2 months, who needed at least four separate restorative visits, requiring local anesthesia participated in this study. On every visit, one of the following 4 different sedative regimen was given (1) 70mg/kg CH (2) 70mg/kg CH and 1mg/kg HD (3) 70mg/kg CH and 2mg/kg HD (4) 70mg/kg CH and 3mg/kg HD. Physiologic parameter was recorded and behavior was videotaped and rated using Ohio State University Behavior Rating Scale by one investigator, blind to the dose. The analyzed sedative effect of combined oral administration of 70mg/kg chloral hydrate and 2mg/kg hydroxyzine was superior to the other regimens. Evidence of adverse effect was not detected or reported during and/or after the procedures.

Key Words: Hydroxyzine, Chloral hydrate, Sedative effect