Journal of the Korean Academy of Pediatric Dentistry 2010;37(2):168-178.
Published online May 31, 2010.
THE ANTIMICROBIAL EFFECT OF HORSERADISH(ARMORACIA RUSTICANA) ROOT EXTRACTS AGAINST ANAEROBES ISOLATED FROM ORAL CAVITY
Yong-Gul Jang1, Ho-Won Park,1, Il-Sik Shin2, Ju-Hyun Lee1, Hyun-Woo Seo1
1Department of Pediatric Dentistry, Oral Science Research Center, College of Dentistry,Gangneung-Wonju National University
2Faculty of Marine Food Science and Technology, Gangneung-Wonju National University 
Correspondence:  Ho-Won Park,,  Tel: 033-640-3158, Email: pedo@kangnung.ac.kr
Received: 21 December 2009   • Accepted: 11 March 2010
Abstract
Objective : The aim of this study was to determine the antimicrobical effect of horseradish root extracts against Enterococcus faecalis and Fusobacterium nucleatum isolated from oral cavity compared with reference strain, and compared with that of chlorhexidine. Method : Horseradish root extracts and chlorhexidine were sequentially diluted and tested against anaerobes( E. faecalis, F. nucleatum) isolated from children’s oral cavity. The microbes were anaerobically incubated and the minimum inhibitory concentration(MIC) and minimum bactericidal concentration(MBC) were detected. Results : 1. Horseradish root extracts showed antimicrobial effect against E. faecalis isolated strain at same or slightly higher concentration compared with MIC of reference strain. 2. 625.0~1,250.0 μg/ml horseradish root extracts showed similar antimicrobial effect with chlorhexidine( 7.8~15.6 μg/ml). 3. Horseradish root extracts showed antimicrobial effect against F. nucleatum isolated strain at same or slightly higher concentration compared with MIC of reference strain. 4. 78.1~312.5 μg/ml horseradish root extracts showed similar antimicrobial effect with chlorhexidine(7.8~15.6 μg/ml).Conclusions : The results of this study confirm that horseradish root extracts has antimicrobial effectagainst anaerobes isolated from oral cavity as well as reference strain. And we found the potential of horseradishroot extracts as a canal irrigant or disinfectant.
Key Words: Horseradish(Armoracia rusticana) root extracts, Allylisothiocyanate(AIT), Anaerobes, Isolation, Chlorhexidine, Antibacterial effect


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